Synthesis and crystal structures of cytotoxic mixed-ligand copper(II) complexes with alkyl tetrazole and polypyridine derivatives

J. A. Eremina, E. V. Lider, N. V. Kuratieva, D. G. Samsonenko, L. S. Klyushova, D. G. Sheven', R. E. Trifonov, V. A. Ostrovskii

Research output: Contribution to journalArticlepeer-review

Abstract

A series of mixed-ligand copper(II) complexes {[Cu(phen)(L1)2]·H2O}n (1), [Cu(dmphen)(L1)2] (2), [Cu(bipy)(L1)2] (3) and [Cu2(dmbipy)2(L1)4] (4), where HL1 – 5-methyltetrazole, bipy – 2,2′-bipyridine, dmbipy – 4,4′-dimethyl-2,2′-bipyridine, phen – 1,10-phenanthroline, dmphen – 4,7-dimethyl-1,10-phenanthroline, has been synthesized. The complexes have been characterized by elemental analysis, IR spectroscopy and powder X-ray diffraction. Crystal structures of some complexes have been determined by single‐crystal X‐ray diffraction analysis and showed distorted tetragonal–pyramidal (1) and square pyramidal ([Cu2(bipy)2(L1)4]·DMSO and 4) geometries. The crystal structure of {(H3O)0.5[Cu(phen)(μ3-H2L2)0.53-HL2)0.5]·H2O}n (5) with alkyl tetrazole H4L2 (1,3,3,5-tetra-(1H-tetrazol-5-yl)-pentane) has also been determined. The complexes 1 and 5 have a zig-zag polymeric structure in which each copper(II) ion is coordinated by five N atoms, belonging to three different tetrazolate rings and one 1,10-phenantroline ligand, while [Cu2(bipy)2(L1)4]·DMSO and 4 are binuclear complexes. The effect of the compounds on viability of MCF-7 and Hep-2 cell lines has been investigated. Complexes 1, 2, 4 possess significant dose-dependent cytotoxic effect and 1, 2 are found to be the most cytotoxic. In addition, stability of copper(II) complexes 1–4 in water-ethanol solution and phosphate buffer saline has been investigated by UV–vis spectroscopy. The interaction of complexes 1 and 3 with calf thymus DNA (CT-DNA) has also been studied by UV–vis spectroscopy.

Original languageEnglish
Article number120169
Number of pages10
JournalInorganica Chimica Acta
Volume516
DOIs
Publication statusPublished - 1 Feb 2021

Keywords

  • Crystal structure
  • Cytotoxicity
  • Mixed-ligand copper(II) complexes
  • Polypyridine
  • Tetrazole
  • OXIDATION
  • POLYMERS
  • BSA BINDING
  • DNA
  • CHEMISTRY
  • FEATURING TETRAZOLYLACETIC ACIDS
  • PALLADIUM(II)

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