Synthesis and biological activity of heterocyclic borneol derivatives

Anastasiya S. Sokolova, Оlga I. Yarovaya, Anna A. Shtro, Marina S. Borisova, Ekaterina A. Morozova, Tatyana G. Tolstikova, Vladimir V. Zarubaev, Nariman F. Salakhutdinov

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    A series of novel heterocyclic derivatives of (-)-borneol has been prepared by the interaction of (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]-heptan-2-yl 2-chloroacetate and (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 3-chloropropanoate with different N- and S-nucleophiles. The obtained products were screened for antiviral, antiulcer, and analgesic activity.

    Original languageEnglish
    Pages (from-to)371-377
    Number of pages7
    JournalChemistry of Heterocyclic Compounds
    Volume53
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2017

    Keywords

    • (–)-borneol
    • 1H-benzimidazole-2-thiol
    • Analgesic activity
    • Antiulcer activity
    • Antiviral activity
    • Benzoxazole-2-thiol
    • Benzthiazole-2-thiol
    • antiulcer activity
    • ACID
    • ASSAY
    • (-)-borneol
    • TOXICITY
    • antiviral activity
    • DISCOVERY
    • benzthiazole-2-thiol
    • analgesic activity
    • INHIBITORS
    • benzoxazole-2-thiol

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