Synthesis and analgesic activity of monoterpenoid aldehyde-derived hydro-2H-chromeneols

Irina Il'ina, Ekaterina Morozova, Dina Korсhagina, Konstantin Volсho, Tat'yana Tolstikova, Nariman Salakhutdinov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Despite a variety of drugs used to stop acute pain, problems related to their insufficient efficacy and undesirable side effects have remained unresolved. Therefore, the search for analgesics of new structural types, which combine high activity with low toxicity, is a topical issue. It is known that a number of compounds with a hydrogenated 2H-chromene skeleton exhibit significant analgesic activity in in vivo tests. Methods: New hydro-2H-chromenols containing monoterpenoid moieties were obtained via one-pot synthesis by the interaction between para-menthane alcohols and commercially available monoterpene aldehydes: Citral, hydroxycitronellal, myrtenal, and perillaldehyde. The analgesic activity of these compounds wаs studied in the acetic acid-induced writhing test and hot plate test. Results: The target compounds were characterized using NMR and HR-MS. Most of them exhibited pronounced analgesic activity. Conclusion: Due to high analgesic activity, (2S,4aR,8R,8aR)-2-((E)-2,6-dimethylhepta-1,5-dien-1-yl)-4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diol is considered as candidate compound to participate in further research.

Original languageEnglish
Pages (from-to)68-78
Number of pages11
JournalLetters in Drug Design and Discovery
Volume17
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Acetic acid-induced writhing test
  • Analgesia
  • Chromene
  • Hot-plate test
  • Isopulegol
  • Monoterpenoid aldehyde
  • isopulegol
  • chromene
  • analgesia
  • ESTERS
  • acetic acid-induced writhing test
  • hot-plate test

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