Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties

K. Yu Ponomarev, E. A. Morozova, E. V. Suslov, D. V. Korchagina, T. G. Tolstikova, K. P. Volcho, N. F. Salakhutdinov

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    Abstract

    A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.

    Original languageEnglish
    Pages (from-to)1131-1136
    Number of pages6
    JournalChemistry of Natural Compounds
    Volume53
    Issue number6
    DOIs
    Publication statusPublished - 1 Nov 2017

    Keywords

    • acetate writhing
    • diazaadamantanes
    • hot plate
    • monoterpenes
    • pain
    • tertiary amines

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