Сурфактантные белки A и D: роль в патогенезе внебольничной пневмонии и возможные прогностические перспективы

Translated title of the contribution: Surfactant proteins A and D: Role in the pathogenesis of community-acquired pneumonia and possible predictive perspectives

O. S. Kharlamovа, K. Y. Nikolaev, Y. I. Ragino, M. I. Voevoda

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Community-acquired pneumonia is one of the most common infectious diseases and remains one of the leading causes of death in this group of diseases. Studies of community-acquired pneumonia are extremely relevant for modern clinical practice. One of the important role in the pathogenesis of bacterial, viral, fungal invasion in the system of a human lung system belongs to the pulmonary surfactant, in particular, its proteins SP-A and SP-D. This article reviews the well-known mechanisms of important biological properties of immunomodulatory activity of the proteins SP-A and SP-D in response to microbial infection in the lungs. The mechanisms of participation of surfactant proteins SP-A and SP-D in the cascade of reactions that lead to severe life-threatening complications in community-acquired pneumonia are considered. The use of serum levels of surfactant proteins SP-A and SP-D can help finding new diagnostic and prognostic approaches in patients with community-acquired pneumonia.

Translated title of the contributionSurfactant proteins A and D: Role in the pathogenesis of community-acquired pneumonia and possible predictive perspectives
Original languageRussian
Pages (from-to)109-115
Number of pages7
JournalTerapevticheskii Arkhiv
Volume92
Issue number3
DOIs
Publication statusPublished - 27 Apr 2020

Keywords

  • surfactant
  • surfactant protein A
  • surfactant protein D
  • biomarker
  • community-acquired pneumonia
  • RESPIRATORY-DISTRESS-SYNDROME
  • PULMONARY SURFACTANT
  • LUNG SURFACTANT
  • SERUM-LEVELS
  • SP-A
  • SP-B
  • INNATE
  • GENE
  • DISEASE
  • EXPRESSION

OECD FOS+WOS

  • 3.02.PY MEDICINE, GENERAL & INTERNAL

State classification of scientific and technological information

  • 76 MEDICINE AND HEALTH CARE

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