1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media

Irina Valerievna Mirzaeva, Irina Valentinovna Andrienko, Ekaterina Aleksandrovna Kovalenko, Ekaterina Aleksandrovna Pashkina, Alina Aleksandrovna Aktanova

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1 Citation (Scopus)

Abstract

The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of 1H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbit[7]uril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbit[7]uril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.

Original languageEnglish
Pages (from-to)1267-1276
Number of pages10
JournalApplied Magnetic Resonance
Volume50
Issue number11
DOIs
Publication statusPublished - 1 Nov 2019

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