1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media

Irina Valerievna Mirzaeva; Irina Valentinovna Andrienko; Ekaterina Aleksandrovna Kovalenko; Ekaterina Aleksandrovna Pashkina; Alina Aleksandrovna Aktanova

doi:10.1007/s00723-019-01147-3

¹H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media

Irina Valerievna Mirzaeva, Irina Valentinovna Andrienko, Ekaterina Aleksandrovna Kovalenko, Ekaterina Aleksandrovna Pashkina, Alina Aleksandrovna Aktanova

Inorganic Chemistry Section

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of ¹H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbit[7]uril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbit[7]uril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.

Original language	English
Pages (from-to)	1267-1276
Number of pages	10
Journal	Applied Magnetic Resonance
Volume	50
Issue number	11
DOIs	https://doi.org/10.1007/s00723-019-01147-3
Publication status	Published - 1 Nov 2019

Keywords

ANTICANCER DRUG CARBOPLATIN
COMPLEXES
OXALIPLATIN
RECOGNITION
HYDROLYSIS
STABILITY
KINETICS
BINDING
ACID

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title = "1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media",

abstract = "The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of 1H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbit[7]uril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbit[7]uril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.",

keywords = "ANTICANCER DRUG CARBOPLATIN, COMPLEXES, OXALIPLATIN, RECOGNITION, HYDROLYSIS, STABILITY, KINETICS, BINDING, ACID",

author = "Mirzaeva, {Irina Valerievna} and Andrienko, {Irina Valentinovna} and Kovalenko, {Ekaterina Aleksandrovna} and Pashkina, {Ekaterina Aleksandrovna} and Aktanova, {Alina Aleksandrovna}",

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doi = "10.1007/s00723-019-01147-3",

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AU - Mirzaeva, Irina Valerievna

AU - Andrienko, Irina Valentinovna

AU - Kovalenko, Ekaterina Aleksandrovna

AU - Pashkina, Ekaterina Aleksandrovna

AU - Aktanova, Alina Aleksandrovna

PY - 2019/11/1

Y1 - 2019/11/1

N2 - The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of 1H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbit[7]uril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbit[7]uril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.

AB - The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of 1H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbit[7]uril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbit[7]uril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.

KW - ANTICANCER DRUG CARBOPLATIN

KW - COMPLEXES

KW - OXALIPLATIN

KW - RECOGNITION

KW - HYDROLYSIS

KW - STABILITY

KW - KINETICS

KW - BINDING

KW - ACID

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U2 - 10.1007/s00723-019-01147-3

DO - 10.1007/s00723-019-01147-3

M3 - Article

AN - SCOPUS:85068845849

VL - 50

SP - 1267

EP - 1276

JO - Applied Magnetic Resonance

JF - Applied Magnetic Resonance

SN - 0937-9347

IS - 11

ER -

¹H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media

Abstract

Keywords

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