15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide

Alexandra Svyatova, Ivan V. Skovpin, Nikita V. Chukanov, Kirill V. Kovtunov, Eduard Y. Chekmenev, Andrey N. Pravdivtsev, Jan Bernd Hövener, Igor V. Koptyug

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Magnetic Resonance Imaging (MRI) is a powerful non-invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal-to-noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized 15N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio-frequency-based SABRE hyperpolarization techniques can be used to obtain 15N MRI of biomolecule 1-15N-nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high-field SABRE for biomedical applications.

Original languageEnglish
Pages (from-to)8465-8470
Number of pages6
JournalChemistry - A European Journal
Volume25
Issue number36
DOIs
Publication statusPublished - 26 Jun 2019

Keywords

  • N MRI
  • hyperpolarization
  • molecular imaging
  • parahydrogen
  • SABRE
  • Nitrogen Isotopes/chemistry
  • Pyridines/chemistry
  • Isotope Labeling
  • Magnetic Resonance Imaging/methods
  • Catalysis
  • Niacinamide/chemistry
  • Coordination Complexes/chemistry
  • MAGNETIZATION
  • HIGH-FIELD
  • N-15 MRI
  • PARAHYDROGEN
  • SIGNAL AMPLIFICATION
  • REVERSIBLE EXCHANGE
  • NMR
  • SPECTROSCOPY
  • METRONIDAZOLE
  • POLARIZATION
  • IN-SITU

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