15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging

Ivan V. Skovpin, Alexandra Svyatova, Nikita Chukanov, Eduard Y. Chekmenev, Kirill V. Kovtunov, Igor V. Koptyug

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize 15N nuclei in dalfampridine. The high polarization level of ca. 8 % achieved in this work made it possible to acquire 15N MR images at natural abundance of the 15N nuclei for the first time.

Original languageEnglish
Pages (from-to)12694-12697
Number of pages4
JournalChemistry - A European Journal
Volume25
Issue number55
DOIs
Publication statusPublished - 23 Jul 2019

Keywords

  • N natural abundance
  • hyperpolarization
  • MRI
  • parahydrogen
  • SABRE
  • SENSITIVITY
  • PARAHYDROGEN
  • SIGNAL AMPLIFICATION
  • REVERSIBLE EXCHANGE
  • NMR
  • ENHANCEMENT
  • METRONIDAZOLE
  • CATALYSTS
  • N-15 natural abundance

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