Substrate specificities of DNA glycosylases in vitro and in vivo

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

DNA glycosylases are enzymes that remove damaged bases from DNA and initiate the process of base excision repair. In vitro, many of these enzymes can excise numerous chemically similar damaged bases, yet their ability to process DNA lesions in the cellular environment is likely narrower. This chapter covers biochemical and genetic evidence for biologically relevant substrates of human and bacterial DNA glycosylases
Original languageEnglish
Title of host publicationDNA Damage, DNA Repair and Disease
Subtitle of host publicationVolume 1
EditorsMiral Dizdaroglu, R Stephen Lloyd
Place of PublicationLondon
PublisherRoyal Society of Chemistry
Chapter8
Pages275-203
Number of pages29
Volume1
ISBN (Electronic)978-1-83916-076-9, 978-1-83916-086-8
ISBN (Print)978-1-78801-889-0
DOIs
Publication statusPublished - 2021

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