Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats

Mikhail Vladimirovich Khvostov, Alexander Anatolievich Chernonosov, Sergey Alkisovich Borisov, Marina Sergeevna Borisova, Elizaveta Sergeevna Meteleva, Veronika Ivanovna Evseenko, Nikolay Eduardovich Polyakov, Alexander Valerievich Dushkin, Tatjana Genrihovna Tolstikova

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Aim: Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). Materials & methods: The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. Results: In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. Conclusion: The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF's hypotensive action.

    Original languageEnglish
    Pages (from-to)119-131
    Number of pages13
    JournalTherapeutic Delivery
    Volume12
    Issue number2
    DOIs
    Publication statusPublished - Feb 2021

    Keywords

    • arabinogalactan
    • bioavailability
    • complexes
    • drug delivery
    • mechanochemistry
    • nifedipine

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