Stabilization of TiO2 sols dispersity at physiological conditions and decrease their cytotoxic properties

Nadezhda V. Shikina, Elena V. Bessudnova, Elena I. Ryabchikova, Asya S. Levina, Valentina F. Zarytova, Zinfer R. Ismagilov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The effect of chemical nature of LiOH, NaOH, KOH and NH4OH electrolytes, surface modification of TiO2 particles with isopropyl glycidyl ether (IGE), mixing order of reactants, and dialysis conditions on the dispersion and cell damage of TiO2 sols at neutral pH has been studied. Investigation of TiO2 sols by a set of physicochemical methods (XRD, Raman spectroscopy, SAXS, AFM, TEM, and ζ-potential measurements) showed the highest dispersity of sols was reached by their neutralization with LiOH. Trypan blue staining and transmission electron microscopy of ultrathin cell sections were used to study in vitro the damaging effect in MDCK cell culture after its incubation with titanium dioxide nanoparticles. It was shown that the surface modification of TiO2 nanoparticles with IGE and phosphate groups diminished its toxic effect on the cells and prevented undesirable interaction of TiO2 with cell components.

Original languageEnglish
Pages (from-to)9312-9321
Number of pages10
JournalJournal of Nanoscience and Nanotechnology
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Aggregation
  • Anatase
  • Damaging effect
  • MDCK cell
  • Nanoparticles
  • Titanium dioxide
  • PARTICLES
  • MDCK Cell
  • Damaging Effect
  • NANOMATERIALS
  • TOXICITY
  • NANOCOMPOSITES
  • Titanium Dioxide
  • CELL-CULTURE
  • MICE
  • TITANIUM-DIOXIDE NANOPARTICLES

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