Comparative sub-population analysis of exosomes from blood plasma of cancer patients

S. N. Tamkovich, N. V. Yunusova, A. K. Somov, S. G. Afanas'ev, G. V. Kakurina, E. S. Kolegova, E. A. Tugurova, P. P. Laktionov, I. V. Kondakova

Research output: Contribution to journalReview articlepeer-review

Abstract

To increase the sensitivity and specificity of the developed methods for diagnosis of oncological diseases using exosomes of blood, a stage of pre-selection of tumor exosomes from a common pool of circulating microvesicles is required. In the present work, universal proteins have been identified, their expression has been increased in the exosomes of patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will further develop a simple and high-performance method of affinity isolation of tumor exosomes.

Translated title of the contributionSravnitel'nyĭ subpopuliatsionnyĭ analiz ékzosom plazmy krovi bol'nykh zlokachestvennymi novoobrazovaniiami
Original languageEnglish
Pages (from-to)110-114
Number of pages5
JournalBiomeditsinskaya Khimiya
Volume64
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Colorectal cancer
  • Exosomes
  • Flow cytometry
  • Head and neck squamous cell carcinoma
  • Lung cancer
  • Proteins
  • Transmission electron microscopy

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