Specifics of anaphase chromatid segregation in Drosophila melanogaster mitotic mutants

L. I. Lebedeva, S. A. Fedorova, L. V. Omelyanchuk

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1 Citation (Scopus)

Abstract

Anaphase chromatid segregation defects (CSDs) were quantitatively and qualitatively studied in neural ganglion cells of third-instar larvae of several control wild type Drosophila melanogaster strains and four strains with mutations of the aar v158 , ff3, mast v40 , and CycB 2g cell cycle genes. A linear specificity was observed for the CSD frequency, type, determination, and correction probability. The probability of anaphase CSD correction was close to unity in the control strains and lower in the mutant strains. The lower correction probability in the mutant strains was explained in the context of two findings, that the mutations induced the CSDs that were atypical of the wild type strains and were potentially uncorrectable in anaphase and that the mutations negatively affected the relative anaphase time in mitosis.

Original languageEnglish
Pages (from-to)919-927
Number of pages9
JournalRussian Journal of Genetics
Volume44
Issue number8
DOIs
Publication statusPublished - Aug 2008

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