Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy

O. E. Redina, T. O. Abramova, L. O. Klimov, M. A. Ryazanova, L. A. Fedoseeva, S. E. Smolenskaya, N. I. Ershov, A. D. Dubinina, A. L. Markel

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Using ISIAH rat strain, an animal model for stress-sensitive form of arterial hypertension, a comparison of the brain stem, hypothalamus, adrenal gland, and kidney transcriptomes for identification of the key genes involved in the development of the stress-sensitive form of arterial hypertension was conducted. Our studies revealed Ephx2 gene encoding soluble epoxide hydrolase (sEH), whose transcription level was significantly higher in all the examined organs. On the basis of other studies and our previous investigations, we concluded the necessity of further studies of Ephx2 gene and an encoded sEH protein as a potential target for pharmacological treatment of stress-sensitive arterial hypertension.

Original languageEnglish
Pages (from-to)972-981
Number of pages10
JournalRussian Journal of Genetics
Volume53
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • arterial hypertension
  • ISIAH rat strain
  • real-time PCR
  • RNA-Seq
  • soluble epoxide hydrolase

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