Simple and efficient modifications of well known techniques for reliable growth of high-quality crystals of small bioorganic molecules

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    14 Citations (Scopus)

    Abstract

    A number of modifications to traditional techniques are suggested in order to overcome problems that frequently arise when growing crystals from solution. These improvements, and their combination, help to avoid problems such as poor nucleation, the spontaneous precipitation of many poor-quality small powder-like crystals, crystals adhering to the crystallization vessel or to each other, and chemical degradation of the solution. The proposed techniques can be used to crystallize desirable metastable polymorphs reliably. None of the suggested methods demands the usage of any special or expensive equipment, or specific skills, and they can be implemented in the chemistry curriculum even at secondary school level. Examples are given for the crystallization of small organic molecules such as carboxylic acids, amino acids, pharmaceuticals etc., but the same techniques are applicable to other classes of compound.

    Original languageEnglish
    Pages (from-to)1435-1442
    Number of pages8
    JournalJournal of Applied Crystallography
    Volume47
    Issue number4
    DOIs
    Publication statusPublished - Aug 2014

    Keywords

    • control of nucleation
    • control of nuclei growth
    • crystal growth from solution
    • Raman spectroscopy
    • seeding
    • X-ray diffraction

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