Shadow coat colour in American mink associated with a missense mutation in the KIT gene

Andrey D. Manakhov, Maria Yu Mintseva, Tatiana V. Andreeva, Oleg V. Trapezov, Evgeny I. Rogaev

Research output: Contribution to journalArticlepeer-review

Abstract

The classical genetic analysis describes more 35 mutations that are involved in the formation of the American mink (Neovison vison) fur colour phenotype. To date, only eight of these mutations have been linked to specific genes. Shadow is a member of the commercially valuable Black cross colour family. Here, we performed whole-genome sequencing of the American mink with a Shadow Silverblue (Sh/+ p/p) phenotype. We identified a missense mutation (c.2374 G>T) in the gene encoding the KIT proto-oncogene, receptor tyrosine kinase gene (KIT), which plays a critical role in melanogenesis as well as in the survival, growth and development of other cell types. The reported mutation results in amino acid substitution p.Asp792Tyr in a highly conserved catalytic loop of the KIT protein.

Original languageEnglish
Pages (from-to)522-525
Number of pages4
JournalAnimal Genetics
Volume53
Issue number4
Early online date28 Apr 2022
DOIs
Publication statusPublished - Aug 2022

Keywords

  • American mink
  • KIT
  • Shadow
  • Hair Color/genetics
  • Phenotype
  • Animals
  • Mink/genetics
  • Color
  • Mutation
  • Mutation, Missense

OECD FOS+WOS

  • 4.02 ANIMAL AND DAIRY SCIENCE
  • 1.06 BIOLOGICAL SCIENCES

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