Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment

Bruna E. dos Santos, Ana C.V.V. Giacomini, Leticia Marcon, Konstantin A. Demin, Tatyana Strekalova, Murilo S. de Abreu, Allan V. Kalueff

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior and drug responses remains poorly understood. Here, we evaluate baseline anxiety-like behavior in adult male and female zebrafish, and its changes following an acute 30-min exposure to 800-μM scopolamine, a common psychoactive anticholinergic drug. Overall, we report high baseline anxiety-like behavior and more individual variability in locomotion in female zebrafish, as well as distinct, sex-specific (anxiolytic-like in females and anxiogenic-like in males) effects of scopolamine. Collectively, these findings reinforce the growing importance of zebrafish models for studying how both individual and sex differences shape behavioral and pharmacological responses.

Original languageEnglish
Article number135993
JournalNeuroscience Letters
Volume759
DOIs
Publication statusPublished - 10 Aug 2021

Keywords

  • Anxiety-like behavior
  • Locomotion
  • Scopolamine
  • Sex differences
  • Temperament
  • Zebrafish

OECD FOS+WOS

  • 3.01 BASIC MEDICAL RESEARCH

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