TY - JOUR
T1 - Role of Tumor Suppressor PTEN and Its Regulation in Malignant Transformation of Endometrium
AU - Perevalova, Alina M.
AU - Kobelev, Vyacheslav S.
AU - Sisakyan, Virab G.
AU - Gulyaeva, Lyudmila F.
AU - Pustylnyak, Vladimir O.
N1 - Publisher Copyright:
© 2022, Pleiades Publishing, Ltd.
PY - 2022/11
Y1 - 2022/11
N2 - Tumor-suppressive effects of PTEN are well-known, but modern evidence suggest that they are not limited to its ability to inhibit pro-oncogenic PI3K/AKT signaling pathway. Features of PTEN structure facilitate its interaction with substrates of different nature and display its activity in various ways both in the cytoplasm and in cell nuclei, which makes it possible to take a broader look at its ability to suppress tumor growth. The possible mechanisms of the loss of PTEN effects are also diverse – PTEN can be regulated at many levels, leading to change in the protein activity or its amount in the cell, while their significance for the development of malignant tumors has yet to be studied. Here we summarize the current data on the PTEN structure, its functions and changes in its regulatory mechanisms during malignant transformation of the cells, focusing on one of the most sensitive to the loss of PTEN types of malignant tumors – endometrial cancer.
AB - Tumor-suppressive effects of PTEN are well-known, but modern evidence suggest that they are not limited to its ability to inhibit pro-oncogenic PI3K/AKT signaling pathway. Features of PTEN structure facilitate its interaction with substrates of different nature and display its activity in various ways both in the cytoplasm and in cell nuclei, which makes it possible to take a broader look at its ability to suppress tumor growth. The possible mechanisms of the loss of PTEN effects are also diverse – PTEN can be regulated at many levels, leading to change in the protein activity or its amount in the cell, while their significance for the development of malignant tumors has yet to be studied. Here we summarize the current data on the PTEN structure, its functions and changes in its regulatory mechanisms during malignant transformation of the cells, focusing on one of the most sensitive to the loss of PTEN types of malignant tumors – endometrial cancer.
KW - endometrial cancer
KW - endometrial hyperplasia
KW - gene regulation
KW - PTEN
UR - http://www.scopus.com/inward/record.url?scp=85142153139&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/d072c0bd-ec5a-33db-aab0-9d7ccfc3ea59/
U2 - 10.1134/S0006297922110104
DO - 10.1134/S0006297922110104
M3 - Review article
AN - SCOPUS:85142153139
VL - 87
SP - 1310
EP - 1326
JO - Biochemistry (Moscow)
JF - Biochemistry (Moscow)
SN - 0006-2979
IS - 11
ER -