Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in DNA repair

A. A. Kosova, S. N. Khodyreva, O. I. Lavrik

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is widely known as a glycolytic enzyme. Nevertheless, various functions of GAPDH have been found that are unrelated to glycolysis. Some of these functions presume interaction of GAPDH with DNA, but the mechanism of its translocation to the nucleus is not fully understood. When in the nucleus, GAPDH participates in the initiation of apoptosis and transcription of genes involved in antiapoptotic pathways and cell proliferation and plays a role in the regulation of telomere length. Several authors have shown that GAPDH displays the uracil-DNA glycosylase activity and interacts with some types of DNA damages, such as apurinic/apyrimidinic sites, nucleotide analogs, and covalent DNA adducts with alkylating agents. Moreover, GAPDH can interact with proteins participating in DNA repair, such as APE1, PARP1, HMGB1, and HMGB2. In this review, the functions of GAPDH associated with DNA repair are discussed in detail.

Original languageEnglish
Pages (from-to)643-654
Number of pages12
JournalBiochemistry (Moscow)
Volume82
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • AP site
  • DNA repair
  • GAPDH
  • glyceraldehyde-3-phosphate dehydrogenase
  • protein–DNA interactions

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