Resting-state fMRI study of patients with fragile X syndrome

E. Isanova, E. Petrovskiy, A. Savelov, D. Yudkin, A. Tulupov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The study aimed to assess the neural activity of different brain regions in patients with fragile X syndrome (FXS) and the healthy volunteers by resting-state functional magnetic resonance imaging (fMRI) on a 1.5 T MRI Achieva scanner (Philips). Results: The fMRI study showed a DMN of brain function in patients with FXS, as well as in the healthy volunteers. Furthermore, it was found that a default mode network of the brain in patients with FXS and healthy volunteers does not have statistically significant differences (p>0.05), which may indicate that the basal activity of neurons in patients with FXS is not reduced. In addition, we have found a significant (p<0.001) increase in the FC within the right inferior parietal and right angular gyrus in the resting state in patients with FXS. Conclusion: New data of functional status of the brain in patients with FXS were received. The significant increase in the resting state functional connectivity within the right inferior parietal and right angular gyrus (p<0.001) in patients with FXS was found.

Original languageEnglish
Article number012007
Number of pages5
JournalJournal of Physics: Conference Series
Volume886
Issue number1
DOIs
Publication statusPublished - 29 Aug 2017

Keywords

  • BRAIN

Fingerprint Dive into the research topics of 'Resting-state fMRI study of patients with fragile X syndrome'. Together they form a unique fingerprint.

Cite this