Representation Analysis of miRNA in Urine Microvesicles and Cell-Free Urine in Prostate Diseases

I. A. Zaporozhchenko, O. E. Bryzgunova, E. A. Lekchnov, I. D. Osipov, M. M. Zaripov, Yu B. Yurchenko, S. V. Yarmoschuk, O. A. Pashkovskaya, E. Yu Rykova, A. A. Zheravin, P. P. Laktionov

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Abstract

Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesicles-associated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urinary extracellular vesicles and demonstrated diagnostic potential of their miRNAs. In this study, we have performed a comparative analysis of 84 miRNA in paired samples of urine microvesicles and urine supernatant from healthy men, patients with benign prostate hyperplasia, and prostate cancer patients using miRCURY LNA miRNA qPCR Panels. In all groups of patients, miRNA subsets characterized by different distribution between the urinary fractions have been found. In this context, two groups of miRNAs have been identified, which are involved in several signaling pathways including those associated with prostate cancer development.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalBiochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • exosomes
  • microvesicles
  • miRNA
  • prostate cancer
  • urine

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    Zaporozhchenko, I. A., Bryzgunova, O. E., Lekchnov, E. A., Osipov, I. D., Zaripov, M. M., Yurchenko, Y. B., Yarmoschuk, S. V., Pashkovskaya, O. A., Rykova, E. Y., Zheravin, A. A., & Laktionov, P. P. (2018). Representation Analysis of miRNA in Urine Microvesicles and Cell-Free Urine in Prostate Diseases. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 12(2), 156-163. https://doi.org/10.1134/S1990750818020142