Reconstruction of Dementia Gene Network Using Online Bioinformatics Tools

Sergey S. Kovalev, Arthur I. Dergilev, Yuriy L. Orlov, Oleg D. Fateev, Urana N. Kavai-Ool

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Abstract

In this work, the set of genes associated with mental diseases such as dementia was examined and analyzed using previously developed gene ontology annotation tools and databases. The aim of the study is to describe the gene ontologies and molecular mechanisms of dementia based on the analysis of the related human gene set using available bioinformatics databases, annotation and recent publications. Dementia is a chronic, general, usually irreversible decrease in cognitive function that affects all aspects of cognitive activity. The enriched gene ontology categories for dementia genes are regulation of neuronal death and cell death, cellular components organization, and cognition. A high connectivity of genes and their products was discovered when studying the structure of the gene network.

Original languageEnglish
Title of host publicationProceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages215-219
Number of pages5
ISBN (Electronic)9781728195971
DOIs
Publication statusPublished - Jul 2020
Event2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020 - Novosibirsk, Russian Federation
Duration: 6 Jul 202010 Jul 2020

Publication series

NameProceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020

Conference

Conference2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
CountryRussian Federation
CityNovosibirsk
Period06.07.202010.07.2020

Keywords

  • bioinformatics
  • dementia
  • gene networks
  • gene ontologies
  • medical genomics

OECD FOS+WOS

  • 1.02 COMPUTER AND INFORMATION SCIENCES
  • 1.06 BIOLOGICAL SCIENCES
  • 3.03 HEALTH SCIENCES
  • 5.09 OTHER SOCIAL SCIENCES
  • 3.01 BASIC MEDICAL RESEARCH

Fingerprint

Dive into the research topics of 'Reconstruction of Dementia Gene Network Using Online Bioinformatics Tools'. Together they form a unique fingerprint.

Cite this