Real time fuctional magnetic resonance imaging biofeedback: A new generation of neurotherapy

M. Ye Mel'nikov, M. B. Shtark, A. A. Savelov, A. Bruhl

    Research output: Contribution to journalReview articlepeer-review


    The review summarizes the data related to the potential of the real time fMRI biofeedback (the rt-fMRI), a novel technology implementing instructing patients to modify the neural activity in the certain brain regions related to the disordered function. The recent positive results were gained for a treatment of the post-stroke impairments, the Parkinson disease, the pain syndrome, the tinnitus, the alcohol and nicotine abuse, the major depression, and phobias of contamination and spiders. The intervention was found to be less promising for schizophrenia and nearly ineffective for the criminal antisocial personality disorder. The reliability of the results is mostly poor due to subopti- mal study designs, lack of the control groups, and insufficient sample sizes. The article deals with biological basis of the technology, its current applications and perspectives, and also its methodological and methodical problems.

    Original languageEnglish
    Pages (from-to)3-32
    Number of pages30
    JournalZhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
    Issue number1
    Publication statusPublished - 1 Jan 2017


    • BOLD response
    • FMRI
    • FMRI informed biofeedback
    • Functional connectivity
    • Machine learning
    • Mental disorders
    • Neu-rotherapy
    • Neurovascular coupling
    • Real time FMRI
    • Region of interest

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