Reactive oxygen species-mediated autophagy defines the fate of cancer stem cells

Matilde E. Lleonart, Etna Abad, Dmitry Graifer, Alex Lyakhovich

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Significance: A fraction of tumorigenic cells, also known as tumor initiating or cancer stem cells (CSCs), is thought to drive tumor growth, metastasis, and chemoresistance. However, little is known regarding mechanisms that convey relevant pathways contributing to their self-renewal, proliferation, and differentiation abilities. Recent Advances: Recent works on CSCs provide evidence on the role of redox disruption and regulation of autophagic flux. This has been linked to increased DNA repair capacity and chemoresistance. Critical Issues: The current review summarizes the most recent studies assessing the role of redox homeostasis, autophagy, and chemoresistance in CSCs, including some novel findings on microRNAs and their role in horizontal transfer within cancer cell populations. Future Directions: Rational anticancer therapy and prevention should rely on the fact that cancer is a redox disease with the CSCs being the apex modulated by redox-mediated autophagy.

Original languageEnglish
Pages (from-to)1066-1079
Number of pages14
JournalAntioxidants and Redox Signaling
Volume28
Issue number11
DOIs
Publication statusPublished - 10 Apr 2018

Keywords

  • autophagy
  • cancer stem cells
  • DNA damage and repair
  • exosomes
  • ferroptosis
  • mitochondria

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