Quantifying the effects of quadrupolar sinks: Via 15N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH

Jonathan R. Birchall, Mohammad S.H. Kabir, Oleg G. Salnikov, Nikita V. Chukanov, Alexandra Svyatova, Kirill V. Kovtunov, Igor V. Koptyug, Juri G. Gelovani, Boyd M. Goodson, Wellington Pham, Eduard Y. Chekmenev

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

15N spin-lattice relaxation dynamics in metronidazole- 15N 3 and metronidazole- 15N 2 isotopologues are studied for rational design of 15N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14N nucleus within the spin-relayed 15N- 15N network.

Original languageEnglish
Pages (from-to)9098-9101
Number of pages4
JournalChemical Communications
Volume56
Issue number64
DOIs
Publication statusPublished - 18 Aug 2020

Keywords

  • REVERSIBLE EXCHANGE
  • SIGNAL AMPLIFICATION
  • CATALYSTS
  • MRI

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