Primary and secondary photochemical transformations of biologically active precursor - Nitro-Nitrosyl ruthenium complex

A. A. Mikhailov, V. A. Vorobyev, V. A. Nadolinny, Y. V. Patrushev, Y. S. Yudina, G. A. Kostin

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Photolysis of [Ru(II)NOPy2(NO2)2OH] (A) complex was studied under blue light (445 nm) irradiation. The primary photo-process results in the formation of nitric oxide (NO) and a paramagnetic RuIII compound, the latter was detected by EPR technique. The quantum yield (6–11%) of primary photolytic process was determined from the evolution of UV–vis spectra in different solvents (water, ethanol, dimethyl sulfoxide and acetonitrile). The secondary processes compete with the NO-release and lead to a variety of ruthenium forms including new nitrosyl forms. Namely, processes of hydroxyl protonation, pyridine photocleavage and nitro – nitrito bond isomerization take a place. HPLC combined with IR and 15N – NMR spectroscopies clarified the composition of the new forms and their transformations during the photolysis. Supporting EPR and IR DFT calculations confirmed the structure of photoproducts. The oxidation of NO in the secondary processes significantly influences on the total amount of nitric oxide release and reaction routes.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalJournal of Photochemistry and Photobiology A: Chemistry
Volume373
DOIs
Publication statusPublished - 15 Mar 2019

Keywords

  • Nitric oxide release
  • Nitrosyl ruthenium
  • Photochemistry
  • Photocleavage
  • NO
  • OXIDE
  • ACID
  • APPROXIMATION
  • CRYSTAL-STRUCTURE
  • REACTIVITY
  • IR
  • LIGHT IRRADIATION
  • NITROSYLRUTHENIUM
  • LIGANDS

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