TY - JOUR
T1 - Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions
AU - Alemasova, Elizaveta E.
AU - Lavrik, Olga I.
N1 - Funding Information:
We express our gratitude to Nikolay Shevchuk for language editing. Physics of LLPS is discussed within the framework of project number 121031300041-4 by the Ministry of Higher Education and Science of Russian Federation. The concept of restricted PS and PAR PS-driving potential are discussed in the frame of project No. 21-64-00017 from the Russian Science Foundation. The concept of percolation-coupled PS as well as PAR PS in cells are discussed within the framework of project No. 22-14-00112 from the Russian Science Foundation.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - Biomolecular condensates are nonmembrane cellular compartments whose formation in many cases involves phase separation (PS). Despite much research interest in this mechanism of macromolecular self-organization, the concept of PS as applied to a live cell faces certain challenges. In this review, we discuss a basic model of PS and the role of site-specific interactions and percolation in cellular PS-related events. Using a multivalent poly(ADP-ribose) molecule as an example, which has high PS-driving potential due to its structural features, we consider how site-specific interactions and network formation are involved in the formation of phase-separated cellular condensates.
AB - Biomolecular condensates are nonmembrane cellular compartments whose formation in many cases involves phase separation (PS). Despite much research interest in this mechanism of macromolecular self-organization, the concept of PS as applied to a live cell faces certain challenges. In this review, we discuss a basic model of PS and the role of site-specific interactions and percolation in cellular PS-related events. Using a multivalent poly(ADP-ribose) molecule as an example, which has high PS-driving potential due to its structural features, we consider how site-specific interactions and network formation are involved in the formation of phase-separated cellular condensates.
KW - condensate
KW - liquid–liquid phase separation (LLPS)
KW - PARP
KW - poly(ADP-ribose) (PAR)
KW - Poly Adenosine Diphosphate Ribose
KW - Macromolecular Substances
UR - http://www.scopus.com/inward/record.url?scp=85142833916&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/1dbf2e53-631a-3602-8758-eadd0e7d947c/
U2 - 10.3390/ijms232214075
DO - 10.3390/ijms232214075
M3 - Review article
C2 - 36430551
AN - SCOPUS:85142833916
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 22
M1 - 14075
ER -