Abstract

Platinum complexes are among the most commonly prescribed drugs in cancer therapy but show significant toxicity to healthy tissues as a side effect. Platinum polyoxometalates are platinum complexes liganded with cluster anions consisting of oxygen atoms and transition metals. Their properties related to a potential use as anticancer drugs have never been studied. In this paper, we have investigated the effect of platinum (IV) polyoxoniobate of the [Nb6O19{Pt(OH)2}]2 structure containing two platinum centers and two polynuclear Lindqvist type anions on the activity of a number of DNA polymerases belonging to different families (Klenow fragment of Escherichia coli DNA polymerase I, bacteriophage RB69 DNA polymerase, human DNA polymerases β and κ, DNA polymerase IV from Sulfolobus solfataricus). On its own, platinum polyoxoniobate did not act as an inhibitor of DNA polymerases, but was capable of forming adducts with DNA.

Original languageEnglish
Pages (from-to)641-646
Number of pages6
JournalRussian Journal of Bioorganic Chemistry
Volume45
Issue number6
DOIs
Publication statusPublished - 1 Nov 2019

Keywords

  • DNA damage
  • DNA polymerases
  • polyoxometalates
  • IN-VITRO
  • POLYOXOMETALATE COMPLEX
  • POLYMERASES
  • FUTURE
  • ANTITUMOR-ACTIVITY

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