Plant Coumarins: XVII. Synthesis and Transformations of 7-Hydroxy-2-oxo-2H-chromene-6-carboxamides

D. O. Zakharov, A. V. Lipeeva, Yu V. Gatilov, A. G. Makarov, E. E. Shults

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Umbelliferone-6-carbonyl chloride reacted with amines and α-, β-, and ω-amino acid methyl esters to afford the corresponding N-substituted 7-hydroxy-2-oxo-2H-chromene-6-carboxamides. The reaction of umbelliferone-6-carbonyl chloride with glycine gave 2-(7-hydroxy-2-oxo-2H-chromene-6-carboxamido)acetic acid which was converted into acid chloride, and the latter reacted with benzylamines and α-amino acid methyl esters to produce compounds containing a dipeptide fragment.

Original languageEnglish
Article number9
Pages (from-to)1518-1526
Number of pages9
JournalRussian Journal of Organic Chemistry
Volume55
Issue number10
DOIs
Publication statusPublished - 1 Oct 2019

Keywords

  • amides
  • amino acids
  • coumarins
  • peptides
  • umbelliferone

OECD FOS+WOS

  • 1.04 CHEMICAL SCIENCES

State classification of scientific and technological information

  • 31 CHEMISTRY

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