Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers

Jonathan R. Birchall, Robert K. Irwin, Panayiotis Nikolaou, Ekaterina V. Pokochueva, Kirill V. Kovtunov, Igor V. Koptyug, Michael J. Barlow, Boyd M. Goodson, Eduard Y. Chekmenev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We present a pilot quality assurance (QA) study of spin-exchange optical pumping (SEOP) performed on two nearly identical second-generation (GEN-2) automated batch-mode clinical-scale 129Xe hyperpolarizers, each utilizing a convective forced air oven, high-power (~170 W) continuous pump laser irradiation, and xenon-rich gas mixtures (~1.30 atm partial pressure). In one study, the repeatability of SEOP in a 1000 Torr Xe/900 Torr N2/100 Torr 4He (2000 Torr total pressure) gas mixture is evaluated over the course of ~700 gas loading cycles, with negligible decrease in performance during the first ~200 cycles, and with high 129Xe polarization levels (avg. %PXe = 71.7% with standard deviation σPXe = 1.5%), build-up rates (avg. γSEOP = 0.019 min−1 with standard deviation σγ = 0.003 min−1) and polarization lifetimes (avg. T1 = 90.5 min with standard deviation σT = 10.3 min) reported at moderate oven temperature of ~70 °C. Although the SEOP cell in this study exhibited a detectable performance decrease after 400 cycles, the cell continued to produce potentially useable HP 129Xe with %PXe = 42.3 ± 0.6% even after nearly 700 refill cycles. The possibility of “regenerating” “dormant” (i.e., not used for an extended period of time) SEOP cells using repeated temperature cycling methods to recover %PXe is also demonstrated. The quality and consistency of results show significant promise for translation to clinical-scale production of hyperpolarized 129Xe contrast agents for imaging and bio-sensing applications.

Original languageEnglish
Article number106755
Number of pages10
JournalJournal of Magnetic Resonance
Volume316
Early online date29 May 2020
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Automation
  • Hyperpolarization
  • Hyperpolarizer
  • Quality assurance
  • SEOP
  • Xenon
  • XENON POLARIZATION
  • MRI
  • LASER-DIODE ARRAYS
  • SPIN-POLARIZED XE-129
  • NMR
  • SPECTROSCOPY
  • MAGNETIC-RESONANCE
  • GAS
  • PERFUSION
  • EXCHANGE

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