Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt

E. S. Meteleva, Yu S. Chistyachenko, L. P. Suntsova, M. A. Tsyganov, G. B. Vishnivetskaya, D. F. Avgustinovich, M. V. Khvostov, N. E. Polyakov, T. G. Tolstikova, V. A. Mordvinov, A. V. Dushkin, N. Z. Lyakhov

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The mechanochemical preparation of solid compositions of praziquantel with plant saponin (glycyrrhizic acid disodium salt) is described. The study of a number of physicochemical parameters showed that dissolving solid compositions in water is accompanied by the inclusion of praziquantel molecules into micelles, which are formed in the solution of the glycyrrhizic acid disodium salt. Using the opisthorchiasis model caused by Opisthorchis felineus, we found a 4- to 11-fold increase in the anthelmintic activity of praziquantel in the composition as compared to the official praziquantel. According to the pharmacokinetic data, the use of the composition increased the bioavailability of praziquantel 3 times.

Original languageEnglish
Pages (from-to)228-231
Number of pages4
JournalDoklady Biochemistry and Biophysics
Volume481
Issue number1
DOIs
Publication statusPublished - 1 Jul 2018

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