Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery

Evgeny Apartsin; Nadezhda Knauer; Valeria Arkhipova; Ekaterina Pashkina; Alina Aktanova; Julia Poletaeva; Javier Sánchez-Nieves; Francisco Javier de la Mata; Rafael Gómez

doi:10.3390/nano10101899

Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery

Evgeny Apartsin, Nadezhda Knauer, Valeria Arkhipova, Ekaterina Pashkina, Alina Aktanova, Julia Poletaeva, Javier Sánchez-Nieves, Francisco Javier de la Mata, Rafael Gómez

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Original language	English
Article number	1899
Pages (from-to)	1-15
Number of pages	15
Journal	Nanomaterials
Volume	10
Issue number	10
DOIs	https://doi.org/10.3390/nano10101899
Publication status	Published - 1 Oct 2020

Keywords

Amphiphile
Carbosilane
Dendron
Doxorubicin
Leukaemia
Methotrexate
PH-sensitive
Self-assembly
Triazine
Vesicles

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title = "Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery",

abstract = "Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.",

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Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery. / Apartsin, Evgeny; Knauer, Nadezhda; Arkhipova, Valeria; Pashkina, Ekaterina; Aktanova, Alina; Poletaeva, Julia; Sánchez-Nieves, Javier; de la Mata, Francisco Javier; Gómez, Rafael.

In: Nanomaterials, Vol. 10, No. 10, 1899, 01.10.2020, p. 1-15.

Research output: Contribution to journal › Article › peer-review

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AU - Apartsin, Evgeny

AU - Knauer, Nadezhda

AU - Arkhipova, Valeria

AU - Pashkina, Ekaterina

AU - Aktanova, Alina

AU - Poletaeva, Julia

AU - Sánchez-Nieves, Javier

AU - de la Mata, Francisco Javier

AU - Gómez, Rafael

PY - 2020/10/1

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AB - Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

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KW - Dendron

KW - Doxorubicin

KW - Leukaemia

KW - Methotrexate

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KW - Self-assembly

KW - Triazine

KW - Vesicles

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Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery

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