Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery

Evgeny Apartsin, Nadezhda Knauer, Valeria Arkhipova, Ekaterina Pashkina, Alina Aktanova, Julia Poletaeva, Javier Sánchez-Nieves, Francisco Javier de la Mata, Rafael Gómez

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Original languageEnglish
Article number1899
Pages (from-to)1-15
Number of pages15
JournalNanomaterials
Volume10
Issue number10
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • Amphiphile
  • Carbosilane
  • Dendron
  • Doxorubicin
  • Leukaemia
  • Methotrexate
  • PH-sensitive
  • Self-assembly
  • Triazine
  • Vesicles

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