Abstract
Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.
Original language | English |
---|---|
Article number | 1899 |
Pages (from-to) | 1-15 |
Number of pages | 15 |
Journal | Nanomaterials |
Volume | 10 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2020 |
Keywords
- Amphiphile
- Carbosilane
- Dendron
- Doxorubicin
- Leukaemia
- Methotrexate
- PH-sensitive
- Self-assembly
- Triazine
- Vesicles
OECD FOS+WOS
- 2.1.NS NANOSCIENCE & NANOTECHNOLOGY
- 2.05.PM MATERIALS SCIENCE, MULTIDISCIPLINARY
- 1.03.UB PHYSICS, APPLIED
- 1.04.DY CHEMISTRY, MULTIDISCIPLINARY