Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.
- 2.1.NS NANOSCIENCE & NANOTECHNOLOGY
- 2.05.PM MATERIALS SCIENCE, MULTIDISCIPLINARY
- 1.03.UB PHYSICS, APPLIED
- 1.04.DY CHEMISTRY, MULTIDISCIPLINARY