Perspectives of boron-neutron capture therapy of malignant brain tumors

V. V. Kanygin, A. I. Kichigin, A. L. Krivoshapkin, S. Yu Taskaev

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Abstract

Boron neutron capture therapy (BNCT) is characterized by a selective effect directly on the cells of malignant tumors. The carried out research showed the perspective of the given kind of therapy concerning malignant tumors of the brain. However, the introduction of BNCT into clinical practice is hampered by the lack of a single protocol for the treatment of patients and the difficulty in using nuclear reactors to produce a neutron beam. This problem can be solved by using a compact accelerator as a source of neutrons, with the possibility of installation in a medical institution. Such a neutron accelerator for BNCT was developed at Budker Institute of Nuclear Physics, Novosibirsk. A neutron beam was obtained on this accelerator, which fully complies with the requirements of BNCT, as confirmed by studies on cell cultures and experiments with laboratory animals. The conducted experiments showed the relative safety of the method with the absence of negative effects on cell cultures and living organisms, and also confirmed the effectiveness of BNCT for malignant brain tumors.

Original languageEnglish
Title of host publicationPhysics of Cancer
Subtitle of host publicationInterdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
EditorsEY Gutmanas, OB Naimark, YP Sharkeev
PublisherAmerican Institute of Physics Inc.
Number of pages10
Volume1882
ISBN (Electronic)9780735415621
DOIs
Publication statusPublished - 28 Sep 2017
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Russian Federation
Duration: 23 May 201726 May 2017

Publication series

NameAIP Conference Proceedings
PublisherAMER INST PHYSICS
Volume1882
ISSN (Print)0094-243X

Conference

ConferenceInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
CountryRussian Federation
CityTomsk
Period23.05.201726.05.2017

Keywords

  • GLIOBLASTOMA-MULTIFORME
  • BORONOPHENYLALANINE
  • DELIVERY
  • BEAM
  • BNCT
  • MELANOMA
  • STRATEGY

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    Kanygin, V. V., Kichigin, A. I., Krivoshapkin, A. L., & Taskaev, S. Y. (2017). Perspectives of boron-neutron capture therapy of malignant brain tumors. In EY. Gutmanas, OB. Naimark, & YP. Sharkeev (Eds.), Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 (Vol. 1882). [020030] (AIP Conference Proceedings; Vol. 1882). American Institute of Physics Inc.. https://doi.org/10.1063/1.5001609