Personalized Approach to Determination of Histidine-Rich Glycoprotein and E-Cadherin in Supernatants of Immunocompetent Blood Cells and Breast Biopsy Specimens in Breast Malignant and Non-Malignant Disease

A. I. Autenshlyus, A. V. Bernado, A. A. Studenikina, A. V. Proskura, K. I. Davletova, I. P. Zhurakovskiy, S. A. Arkhipov, N. A. Varaksin, S. V. Sidorov, V. V. Lyakhovich

Research output: Contribution to journalArticlepeer-review

Abstract

The material of patients with invasive carcinoma of no special type (ICNT) and nonmalignant diseases (ND) of the mammary gland was studied. When comparing the concentrations of histidine-rich glycoprotein (HRG) and E-cadherin (CDH1), statistically significant differences between ICNT and ND by HRG in the supernatant of blood cells and its spontaneous production by biopsies and by CDH1 at its induced production, as well as by influence indices of polyclonal activators on the production of CDH1 were found. When comparing the expression of immunohistochemical markers, no statistically significant differences between ICNT and ND were obtained.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalDoklady Biochemistry and Biophysics
Volume490
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • breast diseases
  • cadherin-E
  • histidine-rich glycoprotein
  • immunohistochemical markers
  • proteomics

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