Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast

A. I. Autenshlyus, A. V. Golovanova, A. A. Studenikina, I. I. Brusentsov, A. V. Proskura, I. P. Zhurakovskiy, S. A. Arkhipov, S. V. Sidorov, V. A. Vavilin, V. V. Lyakhovich

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Abstract: Biopsy material of patients with malignant and benign breast diseases was examined. HRG mRNA expression was detected in 70% of cases in biopsy material obtained from patients with nonspecific invasive carcinoma and in 66.7% of cases in biopsy material of patients with benign breast diseases. Immunohistochemical analysis revealed expression of collagen II, the beta-1 integrin, and E-cadherin—markers of epithelial–mesenchymal transition. The use of RT-qPCR combined with immunohistochemical study made it possible to identify atypical cells, which can be regarded as precancerous changes, in individual patients.

Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalDoklady Biochemistry and Biophysics
Volume484
Issue number1
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • EPITHELIAL-MESENCHYMAL TRANSITION
  • CANCER
  • Cadherins/biosynthesis
  • Humans
  • Middle Aged
  • Gene Expression Regulation, Neoplastic
  • Proteins/genetics
  • Antigens, CD/biosynthesis
  • Neoplasm Proteins/biosynthesis
  • Adolescent
  • Epithelial-Mesenchymal Transition
  • Adult
  • Female
  • Aged
  • Breast Neoplasms/genetics
  • Biomarkers, Tumor/biosynthesis

Fingerprint Dive into the research topics of 'Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast'. Together they form a unique fingerprint.

Cite this