Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives

Veronika V Zlobina; Alexey S Kiryutin; Igor A Nikovskiy; Oleg I Artyushin; Vitaly P Kozinenko; Alexander S Peregudov; Alexandra V Yurkovskaya; Valentin V Novikov

doi:10.3390/ijms24010557

Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives

Veronika V Zlobina, Alexey S Kiryutin, Igor A Nikovskiy, Oleg I Artyushin, Vitaly P Kozinenko, Alexander S Peregudov, Alexandra V Yurkovskaya, Valentin V Novikov

Research output: Contribution to journal › Article › peer-review

Abstract

Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to 1H and 31P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the 31P nucleus.

Original language	English
Article number	557
Journal	International Journal of Molecular Sciences
Volume	24
Issue number	1
Early online date	29 Dec 2022
DOIs	https://doi.org/10.3390/ijms24010557
Publication status	Published - Jan 2023

Keywords

Hydrogen/chemistry
Magnetic Resonance Spectroscopy/methods
Magnetic Resonance Imaging/methods
Hydrogenation
heteroatomic nuclei
magnetic resonance imaging
31P nucleus
signal amplification
polarization transfer
parahydrogen
hyperpolarized probe
phosphates
hyperpolarization
NMR spectroscopy

OECD FOS+WOS

2.04 CHEMICAL ENGINEERING
1.04 CHEMICAL SCIENCES
1.06 BIOLOGICAL SCIENCES

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10.3390/ijms24010557

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@article{3e61f86234b94da5b897d3127525a181,

title = "Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives",

abstract = "Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to 1H and 31P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the 31P nucleus.",

keywords = "Hydrogen/chemistry, Magnetic Resonance Spectroscopy/methods, Magnetic Resonance Imaging/methods, Hydrogenation, heteroatomic nuclei, magnetic resonance imaging, 31P nucleus, signal amplification, polarization transfer, parahydrogen, hyperpolarized probe, phosphates, hyperpolarization, NMR spectroscopy",

author = "Zlobina, {Veronika V} and Kiryutin, {Alexey S} and Nikovskiy, {Igor A} and Artyushin, {Oleg I} and Kozinenko, {Vitaly P} and Peregudov, {Alexander S} and Yurkovskaya, {Alexandra V} and Novikov, {Valentin V}",

note = "Funding: This work was supported by the Russian Science Foundation (interdisciplinary projects 20-62-47038 and 20-63-47107). The authors also acknowledge the Russian Ministry of Science and Higher Education for providing access to NMR facilities at ITC SB RAS and to the equipment of the Center for molecule composition studies at INEOS RAS.",

year = "2023",

month = jan,

doi = "10.3390/ijms24010557",

language = "English",

volume = "24",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

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T1 - Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives

AU - Zlobina, Veronika V

AU - Kiryutin, Alexey S

AU - Nikovskiy, Igor A

AU - Artyushin, Oleg I

AU - Kozinenko, Vitaly P

AU - Peregudov, Alexander S

AU - Yurkovskaya, Alexandra V

AU - Novikov, Valentin V

N1 - Funding: This work was supported by the Russian Science Foundation (interdisciplinary projects 20-62-47038 and 20-63-47107). The authors also acknowledge the Russian Ministry of Science and Higher Education for providing access to NMR facilities at ITC SB RAS and to the equipment of the Center for molecule composition studies at INEOS RAS.

PY - 2023/1

Y1 - 2023/1

N2 - Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to 1H and 31P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the 31P nucleus.

AB - Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to 1H and 31P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the 31P nucleus.

KW - Hydrogen/chemistry

KW - Magnetic Resonance Spectroscopy/methods

KW - Magnetic Resonance Imaging/methods

KW - Hydrogenation

KW - heteroatomic nuclei

KW - magnetic resonance imaging

KW - 31P nucleus

KW - signal amplification

KW - polarization transfer

KW - parahydrogen

KW - hyperpolarized probe

KW - phosphates

KW - hyperpolarization

KW - NMR spectroscopy

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U2 - 10.3390/ijms24010557

DO - 10.3390/ijms24010557

M3 - Article

C2 - 36613997

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 1

M1 - 557

ER -

Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives

Abstract

Keywords

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