Parahydrogen-Induced Hyperpolarization of Gases

Kirill V. Kovtunov, Igor V. Koptyug, Marianna Fekete, Simon B. Duckett, Thomas Theis, Baptiste Joalland, Eduard Y. Chekmenev

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Imaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization. The level of nuclear spin polarization is typically very low, i.e., one hundred thousandth of the potential maximum at 1.5 T and a physiologically relevant temperature. As a result, MRI typically focusses on imaging highly concentrated tissue water. Hyperpolarization methods transiently increase nuclear spin polarizations up to unity, yielding corresponding gains in MRI signal level of several orders of magnitude that enable the 3D imaging of dilute biomolecules including gases. Parahydrogen-induced polarization is a fast, highly scalable, and low-cost hyperpolarization technique. The focus of this Minireview is to highlight selected advances in the field of parahydrogen-induced polarization for the production of hyperpolarized compounds, which can be potentially employed as inhalable contrast agents.

Original languageEnglish
Pages (from-to)17788-17797
Number of pages10
JournalAngewandte Chemie - International Edition
Volume59
Issue number41
Early online date23 Jan 2020
DOIs
Publication statusPublished - 5 Oct 2020

Keywords

  • hyperpolarization
  • MRI
  • NMR
  • parahydrogen
  • spectroscopy
  • RELAXATION
  • PROPANE
  • INERT
  • SIGNAL AMPLIFICATION
  • REVERSIBLE EXCHANGE
  • HYDROGEN INDUCED POLARIZATION
  • FIELD-DEPENDENCE
  • MAGNETIC-RESONANCE
  • EFFICIENT
  • LIVED SPIN STATES

OECD FOS+WOS

  • 1.04 CHEMICAL SCIENCES

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