Optical methods in diagnostics of liver fibrosis via blood observation

Margarita V. Kruchinina, Vladimir M. Generalov, Victor V. Atuchin, Vladimir N. Kruchinin, Vladimir A. Volodin, Andrey A. Gromov, Sergey V. Rykhlitsky

Research output: Contribution to journalConference articlepeer-review

Abstract

A possible application of optical methods (dielectrophoresis, spectral and imaging ellipsometry, Fourier-transform infrared spectroscopy, Raman spectroscopy) for the early diagnostics in studies of red blood cells and serum in patients with the diffuse liver disease, with varying degrees of fibrosis, has been evaluated. As experimentally confirmed, the combined optical methods significantly improve the sensitivity, specificity and accuracy index in the diagnosis of both severe fibrosis and slight ulterior liver fibrosis. The identified optical methods diagnostic potential can be efficiently utilized in noninvasive screening evaluation of the stages of diffuse liver disease of various genesis.

Original languageEnglish
Article number1017608
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume10176
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Blood
  • Film
  • Liver fibrosis
  • Raman
  • Spectroscopic ellipsometry
  • SILICON
  • film
  • PARAMETERS
  • blood
  • liver fibrosis
  • spectroscopic ellipsometry
  • FILMS
  • TEMPERATURE
  • GROWTH
  • CRYSTALS
  • ELECTRONIC-STRUCTURE
  • SURFACES

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