Only Para-Hydrogen Spectroscopy (OPSY) Revisited: In-Phase Spectra for Chemical Analysis and Imaging

Andrey N. Pravdivtsev; Vitaly P. Kozinenko; Jan Bernd Hövener

doi:10.1021/acs.jpca.8b07459

Only Para-Hydrogen Spectroscopy (OPSY) Revisited: In-Phase Spectra for Chemical Analysis and Imaging

Andrey N. Pravdivtsev, Vitaly P. Kozinenko, Jan Bernd Hövener

Department of Physics

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We revisited only para-hydrogen spectroscopy (OPSY) for the analysis of para-hydrogen-enhanced NMR spectra at high magnetic fields. We found that the sign of the gradients and interpulse delays are pivotal for the performance of the sequence: the variant of double-quantum filter OPSY, where the second time interval is twice as long as the first one (OPSYd-12) converts the antiphase spectrum to in-phase and efficiently suppresses the background signal in a single scan better than the other variants. OPSYd-12 strongly facilitates the analysis of para-hydrogen-derived NMR spectra in homogeneous and inhomogeneous magnetic fields. Furthermore, the net magnetization produced is essential for subsequent applications such as imaging, e.g., in a reaction chamber or in vivo.

Original language	English
Pages (from-to)	8948-8956
Number of pages	9
Journal	Journal of Physical Chemistry A
Volume	122
Issue number	45
DOIs	https://doi.org/10.1021/acs.jpca.8b07459
Publication status	Published - 15 Nov 2018

Keywords

PARAHYDROGEN INDUCED POLARIZATION
NMR SIGNAL ENHANCEMENT
SINGLET SPIN STATES
PASADENA HYPERPOLARIZATION
REVERSIBLE EXCHANGE
COHERENT EVOLUTION
ORDER TRANSFER
C-13
RESONANCE
SABRE

Access to Document

10.1021/acs.jpca.8b07459

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Only Para-Hydrogen Spectroscopy (OPSY) Revisited: In-Phase Spectra for Chemical Analysis and Imaging'. Together they form a unique fingerprint.

Cite this

@article{48d29de271644267bc5fccbc15e27764,

title = "Only Para-Hydrogen Spectroscopy (OPSY) Revisited: In-Phase Spectra for Chemical Analysis and Imaging",

abstract = "We revisited only para-hydrogen spectroscopy (OPSY) for the analysis of para-hydrogen-enhanced NMR spectra at high magnetic fields. We found that the sign of the gradients and interpulse delays are pivotal for the performance of the sequence: the variant of double-quantum filter OPSY, where the second time interval is twice as long as the first one (OPSYd-12) converts the antiphase spectrum to in-phase and efficiently suppresses the background signal in a single scan better than the other variants. OPSYd-12 strongly facilitates the analysis of para-hydrogen-derived NMR spectra in homogeneous and inhomogeneous magnetic fields. Furthermore, the net magnetization produced is essential for subsequent applications such as imaging, e.g., in a reaction chamber or in vivo.",

keywords = "PARAHYDROGEN INDUCED POLARIZATION, NMR SIGNAL ENHANCEMENT, SINGLET SPIN STATES, PASADENA HYPERPOLARIZATION, REVERSIBLE EXCHANGE, COHERENT EVOLUTION, ORDER TRANSFER, C-13, RESONANCE, SABRE",

author = "Pravdivtsev, {Andrey N.} and Kozinenko, {Vitaly P.} and H{\"o}vener, {Jan Bernd}",

year = "2018",

month = nov,

day = "15",

doi = "10.1021/acs.jpca.8b07459",

language = "English",

volume = "122",

pages = "8948--8956",

journal = "Journal of Physical Chemistry A",

issn = "1089-5639",

publisher = "American Chemical Society",

number = "45",

}

TY - JOUR

T1 - Only Para-Hydrogen Spectroscopy (OPSY) Revisited

T2 - In-Phase Spectra for Chemical Analysis and Imaging

AU - Pravdivtsev, Andrey N.

AU - Kozinenko, Vitaly P.

AU - Hövener, Jan Bernd

PY - 2018/11/15

Y1 - 2018/11/15

N2 - We revisited only para-hydrogen spectroscopy (OPSY) for the analysis of para-hydrogen-enhanced NMR spectra at high magnetic fields. We found that the sign of the gradients and interpulse delays are pivotal for the performance of the sequence: the variant of double-quantum filter OPSY, where the second time interval is twice as long as the first one (OPSYd-12) converts the antiphase spectrum to in-phase and efficiently suppresses the background signal in a single scan better than the other variants. OPSYd-12 strongly facilitates the analysis of para-hydrogen-derived NMR spectra in homogeneous and inhomogeneous magnetic fields. Furthermore, the net magnetization produced is essential for subsequent applications such as imaging, e.g., in a reaction chamber or in vivo.

AB - We revisited only para-hydrogen spectroscopy (OPSY) for the analysis of para-hydrogen-enhanced NMR spectra at high magnetic fields. We found that the sign of the gradients and interpulse delays are pivotal for the performance of the sequence: the variant of double-quantum filter OPSY, where the second time interval is twice as long as the first one (OPSYd-12) converts the antiphase spectrum to in-phase and efficiently suppresses the background signal in a single scan better than the other variants. OPSYd-12 strongly facilitates the analysis of para-hydrogen-derived NMR spectra in homogeneous and inhomogeneous magnetic fields. Furthermore, the net magnetization produced is essential for subsequent applications such as imaging, e.g., in a reaction chamber or in vivo.

KW - PARAHYDROGEN INDUCED POLARIZATION

KW - NMR SIGNAL ENHANCEMENT

KW - SINGLET SPIN STATES

KW - PASADENA HYPERPOLARIZATION

KW - REVERSIBLE EXCHANGE

KW - COHERENT EVOLUTION

KW - ORDER TRANSFER

KW - C-13

KW - RESONANCE

KW - SABRE

UR - http://www.scopus.com/inward/record.url?scp=85055168009&partnerID=8YFLogxK

U2 - 10.1021/acs.jpca.8b07459

DO - 10.1021/acs.jpca.8b07459

M3 - Article

C2 - 30293421

AN - SCOPUS:85055168009

VL - 122

SP - 8948

EP - 8956

JO - Journal of Physical Chemistry A

JF - Journal of Physical Chemistry A

SN - 1089-5639

IS - 45

ER -