One-pot synthesis of 1,5,3-oxathiazepanes via the three-component condensation of primary amines, formaldehyde and 2-mercaptoethanol

Kseniya S. Kovaleva, Olga I. Yarovaya, Dmitriy S. Fadeev, Nariman F. Salakhutdinov

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The three-component condensation reaction of primary amines, formaldehyde and 2-mercaptoethanol using salts of transition and rare earth metals as catalysts was developed to obtain a new 7-membered heterocyclic structural building block, 1,5,3-oxathiazepanes, in good to excellent yields. The structure of the heterocyclic fragment was confirmed by NMR spectroscopy.

Original languageEnglish
Pages (from-to)1868-1870
Number of pages3
JournalTetrahedron Letters
Volume58
Issue number19
DOIs
Publication statusPublished - 10 May 2017

Keywords

  • 1,5,3-Oxathiazepanes
  • 7-Membered heterocycles
  • One-pot synthesis
  • Three-component reaction
  • MULTICOMPONENT REACTIONS
  • ANTI-HIV ACTIVITY
  • EFFICIENT SYNTHESIS
  • DERIVATIVES
  • CATALYSTS

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