Numerical investigation of diagnostic properties of p53-dependent microRNAs

Olga F. Voropaeva, Sofia D. Senotrusova, Yurii I. Shokin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In the present paper we propose a mathematical model and study numerically the functioning of the p53 tumors suppressor protein and the direct positive connection of microRNA molecules related to it. The adequacy of the model is confirmed by qualitative concordance of calculation results with the experimental data concerning transactivation of specific p53-dependent microRNAs. Estimates of stability of individual and p53-mediated properties of microRNA as factors in diagnosing cancer and neurodegenerative diseases are given within the framework of the accepted model.

Original languageEnglish
Pages (from-to)203-213
Number of pages11
JournalRussian Journal of Numerical Analysis and Mathematical Modelling
Volume32
Issue number3
DOIs
Publication statusPublished - 27 Jun 2017

Keywords

  • delay differential equation
  • Mdm2
  • microRNA
  • Numerical simulation
  • p53
  • tumor marker.

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