In the present paper we propose a mathematical model and study numerically the functioning of the p53 tumors suppressor protein and the direct positive connection of microRNA molecules related to it. The adequacy of the model is confirmed by qualitative concordance of calculation results with the experimental data concerning transactivation of specific p53-dependent microRNAs. Estimates of stability of individual and p53-mediated properties of microRNA as factors in diagnosing cancer and neurodegenerative diseases are given within the framework of the accepted model.
|Number of pages||11|
|Journal||Russian Journal of Numerical Analysis and Mathematical Modelling|
|Publication status||Published - 27 Jun 2017|
- delay differential equation
- Numerical simulation
- tumor marker.