Noncoding RNAs in the Regulation of Pluripotency and Reprogramming

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18 Citations (Scopus)

Abstract

Pluripotent stem cells have great potential for developmental biology and regenerative medicine. Embryonic stem cells, which are obtained from blastocysts, and induced pluripotent stem cells, which are generated by the reprogramming of somatic cells, are two main types of pluripotent cells. It is important to understand the regulatory network that controls the pluripotency state and reprogramming process. Various types of noncoding RNAs (ncRNAs) have emerged as substantial components of regulatory networks. The most studied class of ncRNAs in the context of pluripotency and reprogramming is microRNAs (miRNAs). In addition to canonical microRNAs, other types of small RNAs with miRNA-like function are expressed in PSCs. Another class of ncRNAs, long ncRNAs, are also involved in pluripotency and reprogramming regulation. Thousands of ncRNAs have been annotated to date, and a significant number of the molecules do not have known function. In this review, we briefly summarized recent advances in this field and described existing genome-editing approaches to study ncRNA functions.

Original languageEnglish
Pages (from-to)58-70
Number of pages13
JournalStem Cell Reviews and Reports
Volume14
Issue number1
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • CRISPR/Cas9
  • Genome editing
  • Long noncoding RNA
  • MicroRNA
  • Noncoding RNA
  • Pluripotency
  • Pluripotent stem cells
  • Reprogramming
  • GROUND-STATE
  • WIDE IDENTIFICATION
  • DNA METHYLATION
  • MESENCHYMAL TRANSITION
  • MIR-200 FAMILY
  • SMALL NUCLEOLAR RNA
  • TRANSCRIPTIONAL REPRESSORS
  • MIRNA EXPRESSION
  • EMBRYONIC STEM-CELLS
  • PROFILING REVEALS

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