Non-canonical interaction of DNA repair proteins with intact and cleaved AP sites

Svetlana Khodyreva, Olga Lavrik

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Apurinic/apyrimidinic (AP) sites are widespread lesions in genomic DNA, arising from a number of exogenous and endogenous sources. These DNA lesions are highly mutagenic and demand efficient repair. The review is devoted to data on searching for previously unrecognized proteins capable of interaction with intact or cleaved AP sites. We mainly focused on proteins that form Schiff base upon this interaction. It is important to note that the aldehyde at the deoxyribose C1 atom both in intact and cleaved AP sites can readily react with nucleophiles of proteins. In most cases, these interactions results in processing of AP sites although the process is less efficient as compared to classical AP/dRP lyases. The biological role of these interactions in providing of backup pathways of DNA repair processes is discussed.

Original languageEnglish
Article number102847
Number of pages15
JournalDNA Repair
Volume90
Early online date5 May 2020
DOIs
Publication statusPublished - 1 Jun 2020

Keywords

  • ABH1
  • AP site
  • Ape1
  • Base excision repair
  • Deoxyribose phosphate
  • DNA-protein cross-link
  • GAPDH
  • HMGA
  • HMGB1
  • Ku antigen
  • PARP
  • XRCC1 INTERACTIONS
  • RIBOSOMAL-PROTEIN
  • PHOSPHATE LYASE ACTIVITY
  • SINGLE-NUCLEOTIDE
  • BASE EXCISION-REPAIR
  • POLY(ADP-RIBOSE) POLYMERASE 1
  • ABASIC SITES
  • GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPDH
  • INDUCED CYTOTOXICITY
  • APURINIC/APYRIMIDINIC SITES

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