No Catalyst Added Hydrogen Peroxide Oxidation of Dextran: An Environmentally Friendly Route to Multifunctional Polymers

Ekaterina V. Pronina, Yuri A. Vorotnikov, Tatiana N. Pozmogova, Anastasiya O. Solovieva, Svetlana M. Miroshnichenko, Pavel E. Plyusnin, Denis P. Pishchur, Ilia V. Eltsov, Mariya V. Edeleva, Michael A. Shestopalov, Olga A. Efremova

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The paper demonstrates a "greener" oxidation of dextran polymer of various molecular masses, the component of many industrially and pharmaceutically important materials, by aqueous H2O2 in a no catalyst added setting that produced a multifunctional oxidized dextran. Specifically, on the top of common functional groups (hydroxo, carbonyl, and carboxylic acids), the freshly peroxide oxidized dextran had also a significant number of peroxo-groups, which endowed the polymer with significant cytotoxic properties, as demonstrated on a larynx carcinoma cell line. We also have shown that the peroxo-groups could be easily removed in an alkaline media to yield nontoxic oxidized dextran polymers.

Original languageEnglish
Pages (from-to)5371-5379
Number of pages9
JournalACS Sustainable Chemistry and Engineering
Volume8
Issue number13
DOIs
Publication statusPublished - 6 Apr 2020

Keywords

  • Cytotoxicity
  • Dextran polysaccharide
  • Functional groups
  • Green oxidation
  • Hydrogen peroxide

OECD FOS+WOS

  • 1.04 CHEMICAL SCIENCES
  • 2.04 CHEMICAL ENGINEERING

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