New Ionic Conjugates Based on α-Tocopheryl Succinate as Potential Cytotoxic Agents

Research output: Contribution to journalArticlepeer-review

Abstract

Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments.

Original languageEnglish
Pages (from-to)330-336
Number of pages7
JournalRussian Journal of Bioorganic Chemistry
Volume44
Issue number3
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • antioxidants
  • cytotoxicity
  • ionic conjugates
  • mitocans
  • nitroxide radicals
  • spin-labeled derivatives
  • α-tocopheryl succinate
  • VITAMIN-E
  • ASSAY
  • CANCER
  • SOS CHROMOTEST
  • alpha-tocopheryl succinate
  • TROLOX

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