New crystalline betulin-based materials: improving betulin solubility via cocrystal formation

Svetlana A. Myz; Anastasiya V. Mikhailovskaya; Mikhail A. Mikhailenko; Natalia V. Bulina; Svetlana A. Kuznetsova; Tatyana P. Shakhtshneider

doi:10.1016/j.matpr.2019.03.069

New crystalline betulin-based materials: improving betulin solubility via cocrystal formation

Svetlana A. Myz, Anastasiya V. Mikhailovskaya, Mikhail A. Mikhailenko, Natalia V. Bulina, Svetlana A. Kuznetsova, Tatyana P. Shakhtshneider

Research output: Contribution to journal › Conference article › peer-review

3 Citations (Scopus)

Abstract

The cocrystal formation potential of betulin with aliphatic dicarboxylic acids was investigated. Carboxylic acids of varying carbon chain length, namely: adipic, succinic and suberic acids, were selected to explore the effect of the coformer structure on cocrystal formation when liquid-assisted grinding was used. Cocrystal formation was characterized by powder XRD and IR studies. Betulin cocrystals with adipic acid were successfully synthesized and HPLC analysis showed that solubility of the betulin cocrystal was significantly improved compared to the initial betulin and its mechanocomposite with polymer.

Original language	English
Pages (from-to)	82-85
Number of pages	4
Journal	Materials Today: Proceedings
Volume	12
DOIs	https://doi.org/10.1016/j.matpr.2019.03.069
Publication status	Published - 1 Jan 2019
Event	5th International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT) - Novosibirsk Duration: 25 Jun 2018 → 28 Jun 2018

Keywords

Betulin
dicarboxylic acids
co-grinding
cocrystals
solubility
Dicarboxylic acids
Solubility
Co-grinding
Cocrystals

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10.1016/j.matpr.2019.03.069

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title = "New crystalline betulin-based materials: improving betulin solubility via cocrystal formation",

abstract = "The cocrystal formation potential of betulin with aliphatic dicarboxylic acids was investigated. Carboxylic acids of varying carbon chain length, namely: adipic, succinic and suberic acids, were selected to explore the effect of the coformer structure on cocrystal formation when liquid-assisted grinding was used. Cocrystal formation was characterized by powder XRD and IR studies. Betulin cocrystals with adipic acid were successfully synthesized and HPLC analysis showed that solubility of the betulin cocrystal was significantly improved compared to the initial betulin and its mechanocomposite with polymer.",

keywords = "Betulin, dicarboxylic acids, co-grinding, cocrystals, solubility, Dicarboxylic acids, Solubility, Co-grinding, Cocrystals",

author = "Myz, {Svetlana A.} and Mikhailovskaya, {Anastasiya V.} and Mikhailenko, {Mikhail A.} and Bulina, {Natalia V.} and Kuznetsova, {Svetlana A.} and Shakhtshneider, {Tatyana P.}",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/j.matpr.2019.03.069",

language = "English",

volume = "12",

pages = "82--85",

journal = "Materials Today: Proceedings",

issn = "2214-7853",

publisher = "Elsevier Science B.V.",

note = "5th International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT) ; Conference date: 25-06-2018 Through 28-06-2018",

}

New crystalline betulin-based materials : improving betulin solubility via cocrystal formation. / Myz, Svetlana A.; Mikhailovskaya, Anastasiya V.; Mikhailenko, Mikhail A.; Bulina, Natalia V.; Kuznetsova, Svetlana A.; Shakhtshneider, Tatyana P.

In: Materials Today: Proceedings, Vol. 12, 01.01.2019, p. 82-85.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - New crystalline betulin-based materials

T2 - 5th International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT)

AU - Myz, Svetlana A.

AU - Mikhailovskaya, Anastasiya V.

AU - Mikhailenko, Mikhail A.

AU - Bulina, Natalia V.

AU - Kuznetsova, Svetlana A.

AU - Shakhtshneider, Tatyana P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The cocrystal formation potential of betulin with aliphatic dicarboxylic acids was investigated. Carboxylic acids of varying carbon chain length, namely: adipic, succinic and suberic acids, were selected to explore the effect of the coformer structure on cocrystal formation when liquid-assisted grinding was used. Cocrystal formation was characterized by powder XRD and IR studies. Betulin cocrystals with adipic acid were successfully synthesized and HPLC analysis showed that solubility of the betulin cocrystal was significantly improved compared to the initial betulin and its mechanocomposite with polymer.

AB - The cocrystal formation potential of betulin with aliphatic dicarboxylic acids was investigated. Carboxylic acids of varying carbon chain length, namely: adipic, succinic and suberic acids, were selected to explore the effect of the coformer structure on cocrystal formation when liquid-assisted grinding was used. Cocrystal formation was characterized by powder XRD and IR studies. Betulin cocrystals with adipic acid were successfully synthesized and HPLC analysis showed that solubility of the betulin cocrystal was significantly improved compared to the initial betulin and its mechanocomposite with polymer.

KW - Betulin

KW - dicarboxylic acids

KW - co-grinding

KW - cocrystals

KW - solubility

KW - Dicarboxylic acids

KW - Solubility

KW - Co-grinding

KW - Cocrystals

UR - http://www.scopus.com/inward/record.url?scp=85080144503&partnerID=8YFLogxK

U2 - 10.1016/j.matpr.2019.03.069

DO - 10.1016/j.matpr.2019.03.069

M3 - Conference article

VL - 12

SP - 82

EP - 85

JO - Materials Today: Proceedings

JF - Materials Today: Proceedings

SN - 2214-7853

Y2 - 25 June 2018 through 28 June 2018

ER -

New crystalline betulin-based materials: improving betulin solubility via cocrystal formation

Abstract

Keywords

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