New crystalline betulin-based materials: improving betulin solubility via cocrystal formation

Svetlana A. Myz, Anastasiya V. Mikhailovskaya, Mikhail A. Mikhailenko, Natalia V. Bulina, Svetlana A. Kuznetsova, Tatyana P. Shakhtshneider

Research output: Contribution to journalConference articlepeer-review

3 Citations (Scopus)


The cocrystal formation potential of betulin with aliphatic dicarboxylic acids was investigated. Carboxylic acids of varying carbon chain length, namely: adipic, succinic and suberic acids, were selected to explore the effect of the coformer structure on cocrystal formation when liquid-assisted grinding was used. Cocrystal formation was characterized by powder XRD and IR studies. Betulin cocrystals with adipic acid were successfully synthesized and HPLC analysis showed that solubility of the betulin cocrystal was significantly improved compared to the initial betulin and its mechanocomposite with polymer.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalMaterials Today: Proceedings
Publication statusPublished - 1 Jan 2019
Event5th International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT) - Novosibirsk
Duration: 25 Jun 201828 Jun 2018


  • Betulin
  • dicarboxylic acids
  • co-grinding
  • cocrystals
  • solubility
  • Dicarboxylic acids
  • Solubility
  • Co-grinding
  • Cocrystals


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