Natural products as a source of antiarrhythmic drugs

Arkadiy O. Bryzgalov, Tatjana G. Tolstikova, Elvira E. Shults, Kristina O. Petrova

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Throughout the development of medicine, the spotlight has been held by the search for new drugs blocking different types of arrhythmia. In the past decade, much attention was given to the selection of active antiarrhythmic substances from plant material. It has been shown that these compounds have a good antiarrhythmic effect, and their chemical modifications substantially increase their major effects while adding other beneficial pharmacological properties. In this regard, work on the chemical modification of plant-source antiarrhythmics is highly relevant to the development of new and promising drugs.

Original languageEnglish
Pages (from-to)345-362
Number of pages18
JournalMini-Reviews in Medicinal Chemistry
Volume18
Issue number4
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • Antiarrhythmic drugs
  • Cardiovascular
  • Chemical modifications
  • Ischemic heart disease
  • Plant substances
  • Thyreoidea
  • Animals
  • Anti-Arrhythmia Agents/chemistry
  • Humans
  • Arrhythmias, Cardiac/drug therapy
  • Biological Products/chemistry

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