Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells

Alexey Evdokimov, Irina Petruseva, Aleksei Popov, Olga Koval, Olga Lavrik

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Abstract

Naked mole rat is the long-lived and tumor-resistant rodent. Naked mole rat possesses multiple adaptations that may contribute to longevity and cancer-resistance. Higher activity of DNA excision repair systems and their faster recovery after genotoxic impact as compare with Mus musculus directly demonstrated in our previous investigation contribute to longevity and cancer resistance of naked mole rat. In the present study the DNA-damage-induced apoptosis in naked mole rat fibroblasts was studied using conventional methods. The ability of naked mole rat cells to undergo regulated cell death in response to genotoxic stress is another group of cell defense mechanisms. Naked mole rat skin fibroblasts were demonstrated to be much more resistant towards proapoptotic reagents methyl methanesulfonate, 5-fluorouracil and etoposide as compared with fibroblasts of Mus musculus. Naked mole rat cells have demonstrated limited apoptotic response and seem to undergo also other-type regulated cell death under severe genotoxic stress.

Original languageEnglish
Title of host publicationINTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020)
EditorsO Kovtun, Bazarnyi
PublisherUniversity of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions
Number of pages6
DOIs
Publication statusPublished - 2020
EventInternational Scientific Conference on Longevity Interventions (ICLI) - Ekaterinburg
Duration: 20 Apr 202022 Apr 2020

Publication series

NameBIO Web of Conferences
PublisherE D P SCIENCES
Volume22
ISSN (Print)2117-4458

Conference

ConferenceInternational Scientific Conference on Longevity Interventions (ICLI)
CityEkaterinburg
Period20.04.202022.04.2020

Keywords

  • LONGEVITY
  • RODENT

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