Multivariate analysis identifies eight novel loci associated with meat productivity traits in sheep

Alexander S. Zlobin, Pavel S. Nikulin, Natalia A. Volkova, Natalia A. Zinovieva, Baylar S. Iolchiev, Vugar A. Bagirov, Pavel M. Borodin, Tatiana I. Aksenovich, Yakov A. Tsepilov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Despite their economic value, sheep remain relatively poorly studied animals in terms of the number of known loci and genes associated with commercially important traits. This gap in our knowledge can be filled in by performing new genome‐wide association studies (GWAS) or by re-analyzing previously documented data using novel powerful statistical methods. This study is focused on the search for new loci associated with meat productivity and carcass traits in sheep. With a multivariate approach applied to publicly available GWAS results, we identified eight novel loci associated with the meat productivity and carcass traits in sheep. Using an in silico follow‐up ap-proach, we prioritized 13 genes in these loci. One of eight novel loci near the FAM3C and WNT16 genes has been replicated in an independent sample of Russian sheep populations (N = 108). The novel loci were added to our regularly updated database increasing the number of known loci to more than 140.

Original languageEnglish
Article number367
Pages (from-to)1-11
Number of pages11
JournalGenes
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2021

Keywords

  • GWAS
  • Meat productivity
  • Multivariate analysis
  • Quantitative genetics
  • Sheep

OECD FOS+WOS

  • 3.02 CLINICAL MEDICINE
  • 1.06 BIOLOGICAL SCIENCES
  • 1.06.KM GENETICS & HEREDITY

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