Monolithic rod columns for HPLC based on divinylbenzene-styrene copolymer with 1-vinylimidazole and 4-vinylpyridine

Yuri Patrushev, Yulia Yudina, Vladimir Sidelnikov

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Monolithic chromatographic columns for HPLC based on divinylbenzene-styrene both with 1-vinylimidazole and with 4-vinylpyridine are prepared. The monoliths were synthesized in glass tubes with the inner diameter of 2 mm. Texture, hydrodynamic and chromatographic properties of the prepared columns were studied. Linear solvation energy relationships model was applied for the characterization of columns selectivity It is shown that changing the on 1-vinylimidazole or 4-vinylpyridine content in the initial solution allows to change the selectivity of the columns. An examples of small molecules and some proteins separations are presented.

Original languageEnglish
Pages (from-to)458-466
Number of pages9
JournalJournal of Liquid Chromatography and Related Technologies
Volume41
Issue number8
DOIs
Publication statusPublished - 9 May 2018

Keywords

  • 1-vinylimidazole
  • 4-vinylpyridine
  • HPLC
  • monolithic columns
  • porous polymers
  • SMALL MOLECULES
  • RETENTION
  • SOLVATION ENERGY RELATIONSHIPS
  • STATIONARY PHASES
  • MACROPOROUS POLYMER
  • CAPILLARY COLUMNS
  • PERFORMANCE LIQUID-CHROMATOGRAPHY
  • SEPARATION
  • EFFICIENCY
  • REVERSED-PHASE

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